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KMID : 0981820070270040244
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Korean Journal of Laboratory Medicine
2007 Volume.27 No. 4 p.244 ~ p.247
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A Case of Therapy-Related Acute Monocytic Leukemia following Low-dose of Etoposide Treatment for Hemophagocytic Lymphohistiocytosis
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Seo Young-Ik
Cho Duck
Won Jong-Ho
Park Hee-Sook
Choi Tae-Youn
Lee Nam-Su
Shin Jeong-Won
Park Ro-Jin
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Abstract
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We report a case of therapy-related acute myeloid leukemia after low-dosed topoisomerase II inhibitor (etoposide) treatment for hemophagocytic lymphohistiocytosis (HLH). A 62-yr-old female patient had previously been treated with a HLH-94 protocol containing a low-dose of etoposide (total dose of 300 mg/m2). Thirty-one months later, the patient was admitted to the hematology department with general weakness and upper respiratory infection symptoms. Peripheral blood smear and bone marrow study revealed acute monocytic leukemia. There was no evidence of myelodysplastic syndrome, and a cytogenetic study showed no chromosomal abnormalities. (Korean J Lab Med 2007; 27:244-7)
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KEYWORD
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Etoposide, Hemophagocytic lymphohistiocytosis, Therapy-related acute leukemia
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